What is cirrhosis and how is it related to MASH?

Cirrhosis develops over time as liver damage, caused by MASH (formerly known as NASH) or other factors, leads to formation of scar tissue. This scarring impairs the liver's ability to function properly.

Even with cirrhosis, the liver may continue to work for some time. However, cirrhosis can ultimately lead to liver failure and severe complications1, which can be life-threatening.

Cirrhosis is a stage of permanent liver damage. One cause of cirrhosis is untreated MASH, which can lead to scarring of the liver (fibrosis). Fibrosis ranges from mild to advanced, with the most severe form being cirrhosis.

Other causes include:


• Excessive alcohol consumption
• Viral infections (e.g. Hepatitis B and C)
• Chronic heart failure

At the cirrhosis stage, the liver is no longer functioning properly, leading to noticeable symptoms.

• Fatigue and weakness
• Easy bruising and bleeding
• Jaundice (yellowing of the skin and eyes)
• Itchy skin
• Swelling in the legs, feet, or ankles (edema)
• Abdominal swelling (ascites)
• Spider-like blood vessels on the skin (spider angiomas)
• Red patches on the palms of the hands
• Confusion, drowsiness, and slurred speech (hepatic encephalopathy)
• Nausea
• Loss of appetite
• Weight and muscle loss
• Vomiting blood
• Dark urine and tarry stools
• Swollen legs or abdomen 
• Portal hypertension

Symptoms of cirrhosis can often be challenging to recognize and self-diagnose. Seek professional advice from your healthcare provider if you are at risk of MASH or suspect you are showing symptoms.